NCT03101748: Neratinib and Paclitaxel With or Without Pertuzumab and Trastuzumab Before Combination Chemotherapy in Treating Patients With Metastatic or Locally Advanced Breast Cancer

Breast Cancer Type: HER2+, HR+ & HER2-negative
Hormone Mutations: ER+, PR+
Other Mutations: 
Breast Cancer Tissue: Inflammatory breast cancer (IBC)
Recruitment Status: Active, not recruiting
Phase 1|Phase 2
Drug Category: Therapeutic Antibody, Tyrosine-Kinase Inhibitor, Chemotherapy

Key Eligibility Criteria:

Gender: All
Age: 21 Years and older (Adult, Older Adult)
Location of Metastases: 
Additional Notes: Patients must have HER2+ (IBC or non-IBC) breast cancer to participate in Phase 1b; Patients must have IBC that is NOT TNBC to participate in Phase 2- HER2+ IBC patients are eligible for Cohort 1 & HR+ & HER2-negative IBC patients are eligible for Cohort 2

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