Other Mutations: mTOR

NCT04736589: Inetetamab Plus Rapamycin and Chemotherapy for HER2+ Metastatic Breast Cancer With Abnormal Activation of PAM Pathway

NCT04736589
Breast Cancer Type: HER2+
Hormone Mutations: ER+, PR+
Other Mutations: PI3K, Akt, mTOR
Breast Cancer Tissue: 
Recruitment Status: Not yet recruiting
Phase 3
Drug Category: Serine-Threonine Kinase Inhibitor, Therapeutic Antibody, Tyrosine-Kinase Inhibitor, Chemotherapy

Key Eligibility Criteria:

Gender: Female
Age: 18 Years to 85 Years (Adult, Older Adult)
Location of Metastases: 
Additional Notes: 
Exclusions: Patients with a history of pyrotinib and/or mTOR inhibitors (e.g. Afinitor/everolimus); Patients with symptomatic CNS metastases or evidence of leptomeningeal disease
https://ClinicalTrials.gov/show/NCT04736589

NCT04395989: An Umbrella Trial Based on Molecular Pathway for Patients With Metastatic TNBC

NCT04395989
Breast Cancer Type: Triple Negative
Hormone Mutations: AR+
Other Mutations: HER2, PI3K, Akt, mTOR
Breast Cancer Tissue: 
Recruitment Status: Recruiting
Phase 2
Drug Category: Tyrosine-Kinase Inhibitor, Chemotherapy, Therapeutic Antibody, Serine-Threonine Kinase Inhibitor, Therapeutic Antibody, Immunotherapy

Key Eligibility Criteria:

Gender: Female
Age: 18 Years to 70 Years (Adult, Older Adult)
Location of Metastases: 
Additional Notes: 
Exclusions: Patients with symptomatic, untreated, or actively progressing CNS metastases
https://ClinicalTrials.gov/show/NCT04395989

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