NCT02886585: Pembrolizumab In Central Nervous System Metastases

Breast Cancer Type: HER2+, HR+ & HER2-negative, Triple Negative
Hormone Mutations: ER+, PR+
Other Mutations: 
Breast Cancer Tissue: 
Recruitment Status: Recruiting
Phase 2
Drug Category: Radiation therapy, Therapeutic Antibody, Immunotherapy

Key Eligibility Criteria:

Gender: All
Age: 18 Years and older (Adult, Older Adult)
Location of Metastases: Brain
Additional Notes: Patients with untreated spinal cord or brainstem metastases are eligible if lesions are small & asymptomatic; Patients will be divided into 3 cohorts: untreated brain metastases, progressive brain metastases, & carcinomatous meningitis
Exclusions: Patients with untreated HER2+ primary breast cancer

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