NCT04639245: Genetically Engineered Cells (MAGE-A1-specific T Cell Receptor-transduced Autologous T-cells) and Atezolizumab for the Treatment of Metastatic Triple Negative Breast Cancer, Urothelial Cancer, or Non-small Cell Lung Cancer

Breast Cancer Type: Triple Negative
Hormone Mutations:
Other Mutations: MAGE-A1/3/4/6, HLA+
Breast Cancer Tissue: 
Recruitment Status: Suspended
Phase 1|Phase 2
Drug Category: Therapeutic Antibody, Immunotherapy, Chemotherapy

Key Eligibility Criteria:

Gender: All
Age: 18 Years and older (Adult, Older Adult)
Location of Metastases: 
Additional Notes: Patients who have been previously treated with a PD-1 or PD-L1 inhibitor (e.g. pembrolizumab, nivolumab, avelumab, atezolizumab, durvalumab) & must have also developed progression or still have detectable disease; Patients must have tumors that express HLA-A*02:01
Exclusions: Patients with tumors that express HLA B*4901; Patients with uncontrolled unstable symptomatic brain metastasis- see trial for details

Comments are closed.

Up ↑