NCT04704661: Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Patients With Advanced Solid Tumors Expressing the HER2 Protein or Gene

NCT04704661
Breast Cancer Type: HER2+
Hormone Mutations: ER+, PR+
Other Mutations: 
Breast Cancer Tissue: 
Recruitment Status: Not yet recruiting
Phase 1
Drug Category: Therapeutic antibody, Serine-Threonine Kinase Inhibitor

Key Eligibility Criteria:

Gender: All
Age: 18 Years and older (Adult, Older Adult)
Location of Metastases: Brain, Leptomeningeal Disease
Additional Notes: Breast cancer patients are only eligible for the dose escalation phase of the study; Patients must have progressed on at least 1 line of anti-HER2 therapy; Patients with new or progressive brain metastases (active brain metastases) or leptomeningeal disease are eligible if the treating physician determines that immediate central nervous system (CNS) specific treatment is not required
Exclusions: Patients with previous treatment of an ATR inhibitor; Patients with clinically active central nervous system metastases, defined as untreated & symptomatic, or requiring therapy
https://ClinicalTrials.gov/show/NCT04704661

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