NCT05038735
Breast Cancer Type: HR+ & HER2-negative
Hormone Mutations: ER+, PR+
Other Mutations: PI3K
Breast Cancer Tissue:
Recruitment Status: Recruiting
Phase 3
Drug Category: Endocrine (Hormone Therapy, Serine-Threonine Kinase Inhibitor
Key Eligibility Criteria:
Gender: All
Age: 18 Years and older (Adult, Older Adult)
Location of Metastases:
Additional Notes: Patient must have recurrence or progression of disease during or after combined aromatase inhibitor (AI) (i.e. letrozole, anastrozole, exemestane) & CDK4/6 inhibitor therapy; The combined AI & CDK4/6 inhibitor therapy does not need to be the latest treatment regimen (including adjuvant setting); Patients must have a PIK3CA mutation(s) present in tumor
Exclusions: Patients who have received prior treatment with fulvestrant, any PI3K inhibitor (e.g. Piqray/alpelisib), mTOR inhibitor (e.g. Afinitor/everolimus) or AKT inhibitor (e.g. ONC201)
https://ClinicalTrials.gov/show/NCT05038735